Cardiovascular Research: Cardiac experts find novel approach to treat heart failure ♦ Blood pressure medication can't undo all damage ♦ Cardiac muscle cells as good as progenitors for heart repair

Blood pressure medication can't undo all damage Patients on antihypertensive medications are still at greater risk of cardiovascular disease, despite controlled numbers. A new study sought to determine whether effective treatment of hypertension could lower the risk of cardiovascular disease to that seen in people who have always had ideal blood pressure levels.

Two lefts make it right: Cardiac experts find novel approach to treat heart failure A teenage girl faced with sudden rapid heart deterioration, a man in the prime years of his life suffering from debilitating heart failure and a former NFL athlete crippled by end-stage heart failure were all successfully treated with a surgical approach recently pioneered in California.

Effect of duration of storage of red blood cells transfused for cardiac surgery Although some studies have suggested that transfusion of stored red blood cell (RBC) concentrates may be harmful, as blood undergoes several physiological changes during storage, an analysis of patients who underwent cardiac surgery in Sweden over a 16-year period found no association between duration of RBC storage and risk of death or serious complications.

Cardiac muscle cells as good as progenitors for heart repair Stem cell therapies for post-heart attack tissue repair have had modest success at best. Clinical trials have primarily used bone marrow cells, which can promote the growth of new blood vessels, but many studies have shown no benefit. A better alternative may be to use human heart muscle cells

Iron Supplements Hasten Recovery in Blood Donors

Every year, more than 9 million Americans donate nearly 16 million pints of blood. Blood donors are allowed to give one pint of blood every 8 weeks. But about 25-35% of regular donors develop iron deficiency. The body needs iron to make red blood cells. These cells transport oxygen and carbon dioxide around the body using the iron-rich protein hemoglobin.

It can take months to completely recover the iron and hemoglobin lost from blood donations. Deficiencies can lead to anemia, a condition in which the blood can’t supply enough oxygen to bodily tissues, causing fatigue and other symptoms. Nearly 7% of donors are forced to delay their donation due to low hemoglobin levels. Deferring larger number of donors could greatly affect the already-strained U.S. blood supply.

One potential solution is to provide donors with iron supplements. Past studies have shown that iron supplementation can reduce the number of iron-related deferrals. Researchers led by Dr. Joseph Kiss at the Institute for Transfusion Medicine in Pittsburgh examined how supplements affect blood levels of iron and hemoglobin. Their study was funded by NIH’s National Heart, Lung, and Blood Institute (NHLBI). Results were published on February 10, 2015, in the Journal of the American Medical Association.

The team followed 215 blood donors, ages 18 to 79, at 4 U.S. blood centers. Participants had previously donated blood, but hadn’t given blood within the last 4 months. The researchers measured participants’ levels of ferritin—a protein that stores iron and can be used as an indirect measure of iron levels. The participants donated blood on the first day of the study and then were placed into 2 groups based on their original ferritin levels: higher and lower ferritin. Half of each group took an oral iron supplement daily for the next 168 days, and the other half didn’t.

In both groups, those taking iron supplements showed faster recovery of iron and hemoglobin levels. Compared to donors who didn’t take iron, those taking iron supplements more quickly returned to 80% of pre-donation hemoglobin levels in both the lower ferritin (32 days versus 23 weeks) and higher ferritin groups (31 days versus 11 weeks). Similarly, donors taking iron supplements recovered iron more rapidly. However, the median time for iron to reach pre-donation levels was 11 weeks among those taking supplements and 24 weeks in the no-supplement group.

“This study highlights the importance of maintaining iron levels after blood donation and shows that supplemental iron effectively restores hemoglobin, even in donors with higher iron levels,” Kiss says.

These results suggest that 8 weeks may not be enough time for many donors to sufficiently recover lost iron, particularly without taking iron supplements. Future studies will investigate the optimal dosage and duration of supplementation as well as which donors would benefit from taking iron supplements.