Showing posts with label aging. Show all posts
Showing posts with label aging. Show all posts

Saturday, December 19, 2015

Health Research: Bone drug protects stem cells from aging ♦ Men also recommend getting help for depression ♦ First flu exposure imprints itself on immune system

First flu exposure imprints itself on immune system A person's first infection with the influenza virus likely stimulates the production of key antibodies that then shape later immune responses to different seasonal influenza strains. Now researchers provide insights on how exposure to the flu impacts the immune system, which could be valuable for designing more effective and longer-lasting vaccines.
Men also recommend getting help for depression Participants in a national survey read a scenario describing someone who had depressed symptoms. Men recommended talking to someone about their problems just as much as women did.
Binge drinking with chronic alcohol use more destructive than previously thought Chronic alcohol use, when combined with repeated binge drinking, causes more damage to the liver than previously thought.
Bone drug protects stem cells from aging An existing drug used to treat osteoporosis also protects stem cells from aging, scientists have found. These researchers now want to understand if the drug can be used to revert ageing in stem cells

Friday, December 18, 2015

Senior's Health:Shingles increases short-term risk of stroke in older adults ♦ Genes associated with extreme longevity identified ♦ Aging warps our perception of time

Aging warps our perception of time A recent study found that seniors have a harder time distinguishing the order of events than younger adults. When researchers presented them with both a light and sound at the same or different times, they found that young and older adults could determine whether they occurred simultaneously with similar accuracy. But when asked to determine which appeared first, the light or the sound, older adults performed much worse.
Shingles increases short-term risk of stroke in older adults A new study determined that adults 50 and older are at a 50% increased risk for stroke for 90 days following a shingles episode.
New genes associated with extreme longevity identified Centenarians show successful aging as they remain active and alert at very old ages. Scientists have begun to unravel the basis for longevity by finding genetic loci associated with extreme longevity. A new study uses a new statistical method (termed 'informed GWAS') to identify five longevity loci that provide clues about physiological mechanisms for successful aging
Safety net fails grandmother caregivers living in severe poverty The number of grandmothers raising their grandchildren spiked during the Great Recession, but those living in poverty often struggle with a public assistance system not designed to meet their unique needs

Tuesday, December 8, 2015

Four Articles on epilepsy research

Uncontrolled epilepsy often requires a series of trials and errors to identify effective drug combinations. Continuous, long-term EEG data could streamline this process by revealing the full picture of a patient's seizure activity. Three new personal monitoring devices offer technology that could allow patients to monitor clinical and subclinical seizure activity in the everyday home environment with warning before a seizure strikes.
New findings reveal the interplay between epilepsy and aging The largest and fastest growing segment of people with epilepsy are those over 60. People with epilepsy face a number of related health challenges, including cognitive, physical and psychological disorders. and Other, less expected consequences on the aging process. Four studies g explore the effects of epilepsy on the brain, providing insights that shed light on the long-term implications of life with epilepsy.
Pharmaceutical CBD (cannabidiol) shows promise for children with severe epilepsy Around the globe there is high interest in the use of cannabidiol, for the treatment of people with epilepsy, especially children who have treatment-resistant forms of the disorder. Three studies highlight emerging efficacy and safety data of Epidiolex, a pharmaceutical liquid formulation of cannabidiol. A fourth study highlights possible interactions of CBD with existing anti-epileptic drugs in animal models of seizures.
Unraveling the genetic basis of sudden unexpected death in epilepsy The leading cause of epilepsy-related death is a poorly understood phenomenon known as sudden unexpected death in epilepsy (SUDEP). The risk factors and causes of SUDEP remain unclear but researchers have proposed explanations ranging from irregular heart rhythm to genetic predisposition to accidental suffocation during sleep

Sunday, November 8, 2015

Seniors Health: Older beats younger when it comes to correcting mistakes ♦ Signs of faster aging process identified ♦ Muscle loss linked to falls, fractures in elderly

Signs of faster aging process identified through gene research New research has shed light on the molecular changes that occur in our bodies as we age. In the largest study of its kind, an international group of researchers examined expression of genes in blood samples from 15,000 people across the world. They found 1,450 genes that are linked to aging, and also uncovered a link between these genes and factors such as diet, smoking and exercise.
Older beats younger when it comes to correcting mistakes Findings from a new study challenge the notion that older adults always lag behind their younger counterparts when it comes to learning new things. The study shows that older adults were actually better than young adults at correcting their mistakes on a general information quiz.
Virtual Week' brain game has potential to help older adults remain independent longer Just one month of training on a 'Virtual Week' computer brain game helps older adults significantly strengthen prospective memory -- a type of memory that is crucial for planning, everyday functioning and independent living, an international team of scientists has demonstrated.

Muscle loss linked to falls, fractures in elderly Older people with an age-related loss of muscle mass and strength may be at greater risk of falling and bone fractures, according to new research. A study into sarcopenia -- where muscles lose form and function with age -- found that those with the condition reported higher numbers of falls in the last year and a higher prevalence of fractures.

Friday, October 16, 2015

Cancer Research: Mutations driving leukemia identified ♦Why cancer anemia treatment leads to tumor growth ♦ New test to predict relapse of testicular cancers

Scientists produce clearest-ever images of enzyme that plays key roles in aging, cancer The telomerase enzyme is known to play a significant role in aging and most cancers. Scientists have discovered several major new insights about this enzyme and they are now able to see the complex enzyme's subunits in much sharper resolution than ever before.
New test to predict relapse of testicular cancers Scientists have developed a new test to identify patients who are at risk of suffering a relapse from testicular cancer. Assessing just three features of a common kind of testicular cancer -- called non-seminomatous germ cell tumor -- can identify those at most at risk of relapse even where there is no evidence of tumor spread. The researchers believe the test could be used in the clinic to make decisions about which patients should be given chemotherapy.
Why cancer anemia treatment leads to tumor growth Scientists have shown why a drug widely used to treat chemotherapy-induced anemia in ovarian and breast cancer patients also may shorten survival times in some patients by inadvertently stimulating tumor growth.
Special class of T cells shown to both attack cancer cells and enlist other immune cells New insights about a subset of T cells has been shared by researchers, that suggest that they appear to both inhibit cancer growth and enhance the tumor-killing powers of other immune cells.
Mutations driving leukemia identified An international team of scientists has identified novel genes associated with chronic lymphocytic leukemia through the analysis of high-throughput sequencing data.

Tuesday, August 11, 2015

Senior Health: Getting to the bottom of aging ♦ Seniors at high risk for readmission after ambulatory surgery ♦ Many seniors overestimate their mobility

Picking up the phone to improve mental health in seniors Therapy provided via telephone for older adults in rural areas is effective in treating anxiety disorder, a new study has demonstrated. Experts write that the health-care system lacks the capacity to help the growing elderly population and that relying too heavily on sedative medications isn’t the answer.
Many seniors overestimate their mobility Many seniors who visit emergency departments require more assistance with physical tasks than they think they do, which may lead to hospital readmission later on.
Seniors at high risk for readmission after ambulatory surgery Patients 65 and older who have ambulatory surgery are 54 percent more likely to be readmitted to the hospital within 30 days than younger patients, regardless of their health before surgery, reports a large national study. The likely cause, based on previous research, is difficulty understanding medication dosing and discharge instructions, as well as cognitive impairment among older patients. About 9 million ambulatory surgeries annually are performed on patients 65 and older.
Out-of-home activities may promote older persons' physical activity It is beneficial to stimulate older people to leave home to increase their level of physical activity, suggests a new study that showed that older people were more physically active on the days when they left home and went further away
Getting to the bottom of aging The question of why we age is one of the most fascinating questions for humankind, but nothing close to a satisfactory answer has been found to date. Scientists have now taken one step closer to providing an answer. They have conducted a study in which, for the first time, they have shown that a certain area of the cell, the so-called endoplasmic reticulum, loses its oxidative power in advanced age. If this elixir of life is lost, many proteins can no longer mature properly. At the same time, oxidative damage accumulates in another area of the cell, the cytosol. This interplay was previously unknown and now opens up a new understanding.

Saturday, July 25, 2015

Health Research: Changing the Color of Light ♦ Changing the Color of Light ♦ Fighting mosquito resistance to insecticides ♦ Clues to turning genes off

Changing the Color of Light Researchers have developed a method that could improve medical imaging and cancer treatments and increase the efficiency of commercial solar cells by 25 to 30 percent.
Gene-sequence swap using CRISPR to cure hemophilia For the first time, chromosomal defects responsible for hemophilia have been corrected in patient-specific iPSCs using CRISPR-Cas9 nucleases. Hemophilia A occurs in about 1 in 5,000 male births and almost half of severe cases are caused by identified "chromosomal inversions." In a chromosomal inversion, the order of the base pairs on the chromosome are reversed so the gene doesn't express properly and the sufferer lacks the blood coagulation factor VIII (F8) gene, which causes blood to clot in healthy people.
Fighting mosquito resistance to insecticides Controlling mosquitoes that carry human diseases is a global health challenge as their ability to resist insecticides now threatens efforts to prevent epidemics. Scientists have identified new genetic markers for mosquito resistance to insecticides, which could improve its detection in the field.
Simple flip of genetic switch determines aging or longevity in animals When does aging really begin? Scientists now have a molecular clue. In a study of the roundworm C. elegans, they found that adult cells abruptly begin their downhill slide when an animal reaches reproductive maturity. A genetic switch starts the aging process by turning off cell stress responses that protect the cell by keeping important proteins folded and functional. Germline stem cells throw the switch in early adulthood, after the animal starts to reproduce, ensuring its line will live on.
Clues to turning genes off Scientists have unraveled how an important plant protein, known as TOPLESS, interacts with other molecules responsible for turning genes off. The findings in plants provide a general model across species for this type of gene silencing, which is linked to several vital biological functions in humans.

Saturday, June 20, 2015

Health Research: Link found between neighborhood quality, cellular aging ♦ Genes linked to cataract formation identified ♦ Graphic novella could help prevent hearing loss in Spanish-speaking agricultural workers

Sequential immunizations could be the key to HIV vaccine Scientists have thought for some time that multiple immunizations, each tailored to specific stages of the immune response, could be used to generate a special class of HIV-fighting antibodies, so-called broadly neutralizing antibodies
Drug approved to treat osteoporosis shows promise in preclinical diabetes research A drug commonly used to treat osteoporosis in humans also stimulates the production of cells that control insulin balance in diabetic mice. While other compounds have been shown to have this effect, the drug (Denosumab) is already FDA approved .
Link found between neighborhood quality, cellular aging Regardless of chronological age, people who live in neighborhoods with high crime, noise, and vandalism are biologically more than a decade older than those who do no.
Cataract culprits: Genes linked to cataract formation identified When cataracts encroach on the eyes, the only effective remedy is to surgically replace the eyes' lenses with synthetic substitutes. But what if scientists found a way to delay or prevent cataracts from forming in the first place? Researchers may have found such an opportunity by identifying the prime suspects in the formation of cataracts
Graphic novella could help prevent hearing loss in Spanish-speaking agricultural workers In the Mountain West region, noise-induced hearing loss is common among Spanish-speaking agricultural workers due to their proximity to noise produced by heavy farm equipment and livestock, according to a US Department of Health and Human Services 2013 study. Now researchers are interested in what effect a digital graphic novella will have on Spanish-speaking agricultural workers receiving information about hearing loss and hearing protection.

Saturday, June 6, 2015

Senior Health: Protein that silences the biological clock ♦ Genetic system that affects aging identified ♦ Alzheimer's causes memory loss even before brain degeneration

Alzheimer's culprit causes memory loss even before brain degeneration A brain protein believed to be a key component in the progress of dementia can cause memory loss in healthy brains even before physical signs of degeneration appear.
Natural variants in genetic system that affects aging identified A study of the rapid evolution of the insulin-signaling molecular network that regulates growth, reproduction, metabolism and aging lays important groundwork for future studies.
Scientists discover a protein that silences the biological clock A protein associated with cancer cells is a powerful suppressor of the biological clock that drives the daily ('circadian') rhythms of cells throughout the body. The discovery adds to a growing body of evidence suggesting a link between cancer and disruption of circadian rhythms, while offering new insights into the molecular mechanisms of the biological clock.
End game: Sport can ease the transition into retirement Adjusting to the many changes retirement brings can mean the difference between a positive quality of life and one that struggles under the weight of change. A new study examined sport and its ability to impact the quality of life of a person as he or she transitions to retirement.

Saturday, May 30, 2015

Aging Research: Imaging test may identify biomarker of Alzheimer's disease ♦ Changing activity in the aging brain ♦ Tablets can help elderly cross the 'digital divide'

Researchers discover surprisingly wide variation across species in genetic systems that influence aging A new study focusing on insulin signaling uncovered surprising genetic diversity across reptiles, birds and mammals. Scientists previously assumed the process remained much the same throughout the animal kingdom, but the new research shows that the genetic pathways in reptiles evolved to include protein forms not observed in mammals.
Tablets can help elderly cross the 'digital divide' One way to help the elderly cross what's known as the 'digital divide' is the use of tablets, those smaller, lighter, easy-to-use computers that seem to be taking the place of laptops
Imaging test may identify biomarker of Alzheimer's disease Degeneration of the white matter of the brain may be an early marker of specific types of Alzheimer's disease (AD), including early-onset AD.
Changing activity in the aging brain Normal aging affects our ability to carry out complex cognitive tasks. But exactly how our brain functions change during this process is largely unknown. Now, researchers have demonstrated that aging changes the activity patterns in specific brain regions involved in memory and cognition.
Molecules involved in Alzheimer's have a role in weakening of connections between neurons Molecules that are strongly associated with Alzheimer's disease are important players in a process called long-term depression (LTD), researchers have discovered. LTD is a process through which the strength of synapses, the connections between neurons, is selectively reduced. This new research suggests improperly regulated LTD could cause the degeneration of the connections between neurons that is a core feature of Alzheimer's and other neurodegenerative diseases.

Thursday, May 14, 2015

Food Research: First beef with the omega 3 of fish ♦ Deciphering the neural code that links food to aging D ♦ coffee grounds could make some food more healthful

First beef with the omega 3 of fish Chinese scientists have reared beef rich in the beneficial fatty acids associated with fish oils. The study highlights the scientific challenges that remain following the successful introduction of a gene into fetal cells from Luxi Yellow cattle. The fat1 gene, isolated from a nematode worm, codes for desaturase enzymes that are involved in the conversion of n-6 to n-3 polyunsaturated fatty acids.
Property inhibiting growth of bird flu virus discovered in eggs An egg is many things. It is a versatile food but also an efficient source of bioactive compounds. A researcher has discovered that fractions isolated from the ovomucin protein in egg white can inhibit virus growth.
How noise affects the palate: When flying, taste buds prefer savory tomato  While examining how airplane noise affects the palate, food scientists found umami-rich foods become your taste bud's best buds.
How used coffee grounds could make some food more healthful Coffee has gone from dietary foe to friend in recent years, partly due to the revelation that it's rich in antioxidants. Now even spent coffee grounds are gaining attention for being chock-full of these compounds, which have potential health benefits. Researchers now explain how to extract antioxidants from the grounds. .
Deciphering the neural code that links food to aging Diet exerts a major impact on health and aging. The nervous system plays an important role in this process but, thus far, how food signals are interpreted by the nervous system has been a mystery. A new study has found that serotonin and TGF-beta hormone levels in specific neurons of C. elegans communicate information about food abundance in roundworms. These signals from the nervous system influence the animal's lifespan, thus mediating the effects of food on aging.

Thursday, May 7, 2015

Health Research: Accelerated brain aging in type 1 diabetes ♦ The dark side of cannabis: Panic attacks, nausea ♦ New leads into nerve regeneration

Accelerated brain aging in type 1 diabetes related to cognitive complications The brains of people with type 1 diabetes show signs of accelerated aging that correlate with slower information processing, according to research. The findings indicate that clinicians should consider screening middle-aged patients with type 1 diabetes for cognitive difficulties. If progressive, these changes could influence their ability to manage their diabetes.
Although the use of cannabis as a medical drug is currently booming, we should not forget that leisure time consumption -- for example, smoking weed -- can cause acute and chronic harms. These include panic attacks, impaired coordination of movement, and nausea.
Proteomics provides new leads into nerve regeneration Using proteomics techniques to study injured optic nerves, researchers have identified previously unrecognized proteins and pathways involved in nerve regeneration. Adding back one of these proteins -- the oncogene c-myc -- they achieved unprecedented optic nerve regeneration in mice when combined with two other known strategies.
Profiling approach to enable right lung cancer treatment match A new way to genetically profile lung cancer samples has been developed by researchers, potentially allowing doctors to more easily identify the most appropriate treatment for patients.
Breast cancer vaccines may work better with silicon microparticles The effectiveness of cancer vaccines could be dramatically boosted by first loading the cancer antigens into silicon microparticles, report scientists. Model studies showed that microparticles loaded with an antigen, HER2, not only protected the antigen from premature destruction, but also stimulated the immune system to recognize and relentlessly attack cancer cells overexpressing the HER2 antigen.

Friday, April 17, 2015

Seniors Health:Bone mineral density improved with zoledronic acid ♦ Is the length of work careers determined in utero? ♦ Eight nutrients to protect the aging brain

Bone mineral density improved in frail elderly women treated with zoledronic acid A single intravenous dose of the osteoporosis drug zoledronic acid improved bone mineral density in a group of frail elderly women living in nursing homes and long-term-care facilities.
Is the length of work careers determined in utero? Low weight at birth increased the risk of disability pension among men. Around 20% of the cohort members born in 1934–44 retired on a disability pension between 1971 and 2011.
Civic engagement may stave off brain atrophy, improve memory Instead of shrinking as expected, as part of the normal aging process, the memory center in the brains of seniors maintained their size and, in men, grew modestly after two years in a program that engaged them in meaningful and social activities.
Eight nutrients to protect the aging brain  Brain health is the second most important component in maintaining a healthy lifestyle according to a 2014 AARP study. As people age they can experience a range of cognitive issues from decreased critical thinking to dementia and Alzheimer’s disease. Researchers write about eight nutrients that may help keep your brain in good shape

Monday, January 5, 2015

Osteoporosis in Aging - Protect Your Bones with Exercise

Illustration of 2 people playing tennis.
Bones feel solid, but the inside of a bone is actually filled with holes like a honeycomb. Bone tissues are broken down and rebuilt all the time. While some cells build new bone tissue, others dissolve bone and release the minerals inside.
As we get older, we begin to lose more bone than we build. The tiny holes within bones get bigger, and the solid outer layer becomes thinner. In other words, our bones get less dense. Hard bones turn spongy, and spongy bones turn spongier. If this loss of bone density goes too far, it’s called osteoporosis. Over 10 million people nationwide are estimated to have osteoporosis.
It’s normal for bones to break in bad accidents. But if your bones are dense enough, they should be able to stand up to most falls. Bones weakened by osteoporosis, though, are more likely to break.
“It’s just like any other engineering material,” says Dr. Joan McGowan, an NIH expert on osteoporosis. If you fall and slam your weight onto a fragile bone, “it reaches a point where the structures aren’t adequate to support the weight you’re putting on them.” If the bone breaks, it’s a major hint that an older person has osteoporosis.
Broken bones can lead to serious problems for seniors. The hip is a common site for osteoporosis, and hip fractures can lead to a downward spiral of disability and loss of independence. Osteoporosis is also common in the wrist and the spine.
The hormone estrogen helps to make and rebuild bones. A woman’s estrogen levels drop after menopause, and bone loss speeds up. That’s why osteoporosis is most common among older women. But men get osteoporosis, too.
“A third of all hip fractures occur in men, yet the problem of osteoporosis in men is frequently downplayed or ignored,” says Dr. Eric Orwoll, a physician-researcher who studies osteoporosis at Oregon Health and Science University. Men tend to do worse than women after a hip fracture, Orwoll says.
Experts suggest that women start getting screened for osteoporosis at age 65. Women younger than age 65 who are at high risk for fractures should also be screened. Men should discuss screening recommendations with their healthcare providers.
Screening is done with a bone mineral density test at the hip and spine. The most common test is known as DXA, for dual-energy X-ray absorptiometry. It’s painless, like having an X-ray. Your results are often reported as a T-score, which compares your bone density to that of a healthy young woman. A T-score of −2.5 or lower indicates osteoporosis.
There’s a lot you can do to lower your risk of osteoporosis. Getting plenty of calcium, vitamin D, and exercise is a good start, Orwoll says.
Calcium is a mineral that helps bones stay strong. It can come from the foods you eat—including milk and milk products, dark green leafy vegetables like kale and collard greens—or from dietary supplements. Women over age 50 need 1,200 mg of calcium a day. Men need 1,000 mg a day from ages 51 to 70 and 1,200 mg a day after that.
Vitamin D helps your body absorb calcium. As you grow older, your body needs more vitamin D, which is made by your skin when you’re in the sun. You can also get vitamin D from dietary supplements and from certain foods, such as milk, eggs, fatty fish, and fortified cereals. Talk with your healthcare provider to make sure you’re getting a healthy amount of vitamin D. Problems can arise if you’re getting too little or too much.
Exercise, especially weight-bearing exercise, helps bones, too. Weight-bearing exercises include jogging, walking, tennis, and dancing. The pull of muscles is a reminder to the cells in your bones that they need to keep the tissue dense.
Smoking, in contrast, weakens bones. Heavy drinking does too—and makes people more likely to fall. Certain drugs may also increase the risk of osteoporosis. Having family members with osteoporosis can raise your risk for the condition as well.
The good news is, even if you already have osteoporosis, it’s not too late to start taking care of your bones. Since your bones are rebuilding themselves all the time, you can help push the balance toward more bone growth by giving them exercise, calcium, and vitamin D.
Several medications can also help fight bone loss. The most widely used are bisphosphonates. These drugs are generally prescribed to people diagnosed with osteoporosis after a DXA test, or to those who've had a fracture that suggests their bones are too weak. Bisphosphonates have been tested more thoroughly in women, but are approved for men too.
Researchers are trying to develop drugs that increase bone growth. For now, there’s only one available: parathyroid hormone. It’s effective at building bone and is approved for women and men with osteoporosis who are at high risk for having a fracture.
Another important way to avoid broken bones is to prevent falling and occasions for fracture in the first place. Unfortunately, more than 2 million so-called fragility fractures (which wouldn’t have happened if the bones had been stronger) occur nationwide each year. “To reduce the societal burden of fracture, it’s going to take a combined approach of not only focusing on the skeleton but focusing on fall prevention,” says Dr. Kristine Ensrud, a physician-researcher who studies aging-related disorders at the University of Minnesota and Minneapolis VA Health Care System.
Source NIH

Saturday, October 25, 2014

10/25/14 Health News: LAWSUIT FILED TO BLOCK APPROVAL OF ENLIST DUO HERBICIDE ♦ Soda Making You Age Faster ♦ Should Hospitals Withholding Care to Ebola Patients

ANOTHER LAWSUIT FILED TO BLOCK EPA APPROVAL OF ENLIST DUO HERBICIDE
The Center for Food Safety and Earthjustice filed a lawsuit on Wednesday against the U.S. Environmental Protection Agency (EPA) challenging the approval of Dow Chemical’s Enlist Duo herbicide, a blend of 2,4-D and glyphosate. The suit was filed in the U.S. Ninth Circuit Court of Appeals on behalf of Beyond Pesticides, Center for Biological Diversity, Center... Continue Reading
Your Afternoon Soda Could Be Making You Age Faster
If the threat of heart disease, diabetes, or obesity wasn’t enough to make you put down your afternoon cola, this might: A new study published in the American Journal of Public Health reports that drinking one sugary soda a day may speed up the rate at which your body ages. Continue Reading
U.S. Hospitals Weigh Withholding Care to Ebola Patients

The Ebola crisis is forcing the American healthcare system to consider the previously unthinkable: withholding some medical interventions because they are too dangerous to doctors and nurses and unlikely to help a patient. U.S. hospitals have over the years come under criticism for undertaking measures that prolong dying rather than improve patients… Continue Read

Monday, September 22, 2014

Fruit Flies Yield Insights Into Human Aging

At a Glance
  • Activating certain molecules in key tissues slowed aging in fruit flies.
  • The findings may lead to a better understanding of aging processes in people.
Both calorie restriction and resveratrol—a compound found in grapes, red wine, and nuts—ward off several age-related diseases in animal models. Researchers have been exploring the molecular mechanisms involved. Recent studies have implicated an enzyme called AMP-activated protein kinase (AMPK). AMPK senses and maintains energy levels in the cell. Among its many effects, it helps to regulate autophagy, a recycling process that continually breaks down and recycles waste within our cells. Autophagy has also been linked to aging and lifespan.
A fruit fly.
Studies of fruit flies offer insights into human aging.
A team led by Dr. David Walker at the University of California, Los Angeles, used transgenic technology to manipulate AMPK levels in specific organs of fruit flies (Drosophila) and explored the impact on autophagy, cellular signs of aging, and lifespan. Results appeared online inCell Reports on September 3, 2014.
The researchers found that boosting AMPK levels in the nervous system (neurons) induced autophagy within the brain and prolonged the flies’ lifespan. Surprisingly, boosting neuronal AMPK also induced autophagy in the flies’ intestines and improved a measure of intestinal aging. It induced autophagy and reduced signs of aging in muscle as well.
Autophagy can be directly induced in Drosophila by increasing expression of the gene Atg1. When the researchers raised expression of Atg1 in adult fly neurons, it also improved intestinal function during aging and prolonged lifespan. Further experiments showed that the anti-aging effects of neuronal AMPK disappeared when Atg1 was blocked.
The team next raised levels of AMPK in the intestine. This similarly boosted autophagy, both in the intestine and the brain. It also reduced signs of aging in muscle tissue and prolonged life.
To investigate how AMPK and Atg1 might exert these system-wide effects, the researchers explored the insulin/insulin-growth-factor-1-signaling pathway, which had previously been linked to lifespan in flies and mammals. Their results suggest that AMPK and Atg1 affect other tissues by altering insulin-like peptide signaling.
“We have shown that when we activate the [AMPK] gene in the intestine or the nervous system, we see the aging process is slowed beyond the organ system in which the gene is activated,” Walker says.
Autophagy may slow the aging process by increasing the turnover of damaged cell components. Which of these components might be relevant to aging remains to be discovered. Researchers will also need to test whether activation of autophagy in a single tissue in mammals can slow aging in other tissues as well.
—by Harrison Wein, Ph.D.

Sunday, March 30, 2014

3/30/14 Health News: Cancer Risk for Kids Living Near Busy Roads ♦ Salt and Obesity May Prematurely Age Cells ♦ More of the Infections Kids Get Are Resistant to Drugs

Salt and Obesity May Prematurely Age Young Cells
High sodium intake and obesity may act synergistically to accelerate cellular aging in adolescents, according to new research presented at the American Heart Association's EPI/NPAM Scientific Sessions 2014. The study examined the effect of a high salt diet on telomere length in normal weight and overweight/obese teens. After controlling for factors known to shorten telomeres, researchers observed a statistically significant interaction between weight and sodium intake.Continue Reading
More of the Infections Kids Get Are Resistant to Drugs
The rate of antibiotic-resistant bacterial infections in children is increasing in inpatient and outpatient settings, a study reports. The prevalence of third-generation cephalosporin-resistant (G3CR) bacteria increased from 1.39% in 1999-2001 to 3% in 2010-2011, wrote Latania K. Logan, MD, of Rush University Medical Center in Chicago, and her co-authors online in the Journal of the Pediatric Infectious Disease Society.Continue Reading

Higher Cancer Risk for Kids Living Near Busy Roads

Young children who are exposed to high levels of vehicle exhaust — such as what they'd encounter living near busy roads in urban areas — appear to have a greater risk of childhood leukemia, according to a Centers for Disease Control and Prevention review of seven previous studies. Iin the USA an estimated 30%-45% of people in large urban areas live near major roads, "suggesting increased exposure to traffic-related air pollution and risk of adverse health outcomes." The article says the studies reviewed by the CDC suggest "that childhood leukemia is associated with residential traffic exposure during the postnatal period, but not during the prenatal period." Continue Reading

Wednesday, January 15, 2014

1/15/14 Health News: SALMONELLOSIS:BIGGEST FOODBORNE KILLER - Racism Speed Cellular Aging - Diabetic Crises Tied to Food Budgets

SALMONELLOSIS: THE BIGGEST FOODBORNE KILLER
In 2013, the U.S. Centers for Disease Control and Prevention (CDC) reported that more than 500 people were sickened by seven strains of Salmonella Heidelberg linked to chicken. However, salmonellosis caused by Salmonella Heidelberg is only in fourth place, according to CDC’s outbreak data; in 2011, it was only in seventh place. Salmonellosis is “old... Continue Reading

Racism May Speed Cellular Aging in African American Men
Researchers at the University of Maryland reported that racism appears to accelerate aging in cells. In a first-ever study of its type, researchers found that African American men who reported experiencing negative effects from racial discrimination have shorter telomeres, the DNA sequences at the ends of chromosomes that are considered biomarkers for biological aging. Telomeres (officially known as leukocyte telomeres) shorten over the course of a lifetime, and previous research has connected shorter telomeres with an increased likelihood of premature death. Shorter telomeres have also been associated with life-shortening diseases such as diabetes, stroke, heart disease and dementia.continue reading

Study Ties Diabetic Crises to Dip in Food Budgets

Poor people with diabetes are significantly more likely to go to the hospital for dangerously low blood sugar at the end of the month when food budgets are tight than at the beginning of the month, a new study has found. Researchers found no increase in such hospitalizations among higher-income people for the condition known as hypoglycemia, suggesting that poverty and exhausted food budgets may be a reason for the increased health risk. continue reading