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Tuesday, June 23, 2015

Cancer Research: Parkinson's disease appears associated with many cancer ♦ Supercomputers surprisingly link DNA crosses to cancer ♦ Tubal ligation may improve prognosis of endometrial cancer



Parkinson's disease appears associated with many cancers in Taiwan Parkinson's disease appeared associated with 16 types of cancer in a study in Taiwan, an effort to explain the association in an East Asian population because most prior research has been conducted in Western populations.
Researchers discover mechanism leading to BRAF inhibitor resistance in melanoma patients The development of targeted therapies has significantly improved the survival of melanoma patients over the last decade; however, patients often relapse because many therapies do not kill all of the tumor cells, and the remaining cells adapt to treatment and become resistant. Researchers have discovered a novel mechanism that can lead melanoma cells to develop resistance to drugs that target the protein BRAF.
Supercomputers surprisingly link DNA crosses to cancer DNA naturally folds itself into cross-shaped structures called cruciforms that jut out along the sprawling length of its double helix. DNA cruciforms are abundant; scientists estimate as many as 500,000 cruciform-forming sequences may exist on average in a normal human genome. Supercomputers have now helped scientists find a surprising link between cross-shaped (or cruciform) pieces of DNA and human cancer.
Tubal ligation may improve prognosis of endometrial cancer later in life Endometrial cancer (EC) can spread by several routes, including the lymph system, blood vessels, through the uterine wall, as well as through the fallopian tubes into the peritoneal cavity, but the association of transtubal dissemination of EC with cancer stage, histological type, and mortality is unknown.

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