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Friday, November 14, 2014

Sun screen ultraviolet filters linked to pregnancy delays

Researchers identify two chemicals that appear to reduce fertility in men
Certain sunscreen chemicals used to protect against ultraviolet rays may impair men’s ability to father children in a timely manner, according to a study by the National Institutes of Health and the New York state Department of Health’s Wadsworth Center. But the researchers caution that the results are preliminary and that additional studies are needed to confirm their findings.
Benzophenone (BP)-type ultraviolet (UV) filters comprise a class of about 29 chemicals commonly used, among other purposes, in sunscreens and other personal care products to protect skin and hair from sun damage. Some of these chemicals, upon being absorbed by the skin, can interfere with the body’s hormones and endocrine system processes. Researchers found that men with high exposure to UV filters BP-2 or 4OH-BP had a 30 percent reduction in fecundity, the biological ability to reproduce. Lower fecundity may result in a longer time to pregnancy.
“In our study, male fecundity seems to be more susceptible to these chemicals than female fecundity. The women participants actually had greater exposure to the UV filters overall, but their exposure wasn’t associated with any significant pregnancy delays,” said Germaine Louis, Ph.D., director of the Division of Intramural Population Health Research at the Eunice Kennedy Shriver National Institute of Child Health and Human Development. “Our next step is to figure out how these particular chemicals may be affecting couple fecundity or time to pregnancy—whether it’s by diminishing sperm quality or inhibiting reproduction some other way.”
The researchers followed the couples until pregnancy or up to one year of trying, to record the time it took for the women to become pregnant. They also tested participants’ urine samples and measured concentrations of five selected UV filters associated with endocrine-disrupting activity. In their data analysis, the researchers controlled for age, body mass index, and smoking, among other factors.
Their findings suggest that some, but not all, UV filters may be associated with diminished fertility in men, independent of their partners’ exposure. The researchers observed effects among men with the highest exposure (the 75th percentile and above) to UV filters BP-2 or 4OH-BP.
“The skin is the body’s largest organ, and how we care for our skin matters in more ways than one,” said Dr. Louis. “Sunscreen is important for sun protection, and we definitely encourage people to continue using sunscreen to avoid skin cancer. But men who are concerned about fertility may be interested in other ways to reduce their exposure to benzophenone UV filters—whether by cutting back on other products that contain the UV filters or by washing after returning indoors.”
Among the study’s major limitations: the researchers tested single urine samples from participants to assess chemical exposure, but participants’ levels of exposure may have changed over the course of trying for pregnancy. The researchers also had no data on what specific products the participants used that contained the UV filters.
Earlier research findings from the LIFE Study have linked reduced fertility to high cholesterol levels in women and couples and to high concentrations of phthalates and Bisphenol A (BPA) in men.

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