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Tuesday, November 3, 2015

Cancer Research: Heat-activated ‘grenade’ to target cancer ♦ Predicting cancer's growth from few clues ♦ Brain tumor-shrinking molecules

Heat-activated ‘grenade’ to target cancer Researchers have developed cancer drug-packed ‘grenades’ armed with heat sensitive triggers, allowing for treatment to be targeted directly at tumors.
New computational strategy finds brain tumor-shrinking molecules Patients with glioblastoma, a type of malignant brain tumor, usually survive fewer than 15 months following diagnosis. Since there are no effective treatments for the deadly disease, researchers developed a new computational strategy to search for molecules that could be developed into glioblastoma drugs. In mouse models of human glioblastoma, one molecule they found shrank the average tumor size by half.
Predicting cancer's growth from few clues Duke mathematicians are developing ways to help doctors predict how different cancers are likely to progress when measurements of tumor growth are hard to come by. In a new study, they describe a way to compare common models of tumor growth, using only two time-point measurements of tumor size -- often the maximum available before patients begin treatment. Determining which models work best for different cancers is key to designing optimum treatment strategies.
Cancer cells use secret tunnels to communicate, smuggle cancer signals their neighbors Cancer cells use previously unknown channels to communicate with one another and with adjacent non-cancerous cells, a new report suggests. The researchers report that an in vitro co-culture system robustly quantifies the transfer of fluorescent proteins between cells and can also compare between various conditions

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