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Thursday, October 29, 2015

:3-D pancreatic cancer may help predict clinical responses, ♦ New clues for blocking cancer gene ♦ Inherited gene increased risk of childhood cancer

Genetic testing could identify men at a 10-fold increased risk of testicular cancer A new study of more than 25,000 men has uncovered four new genetic variants associated with increased risk of testicular cancer. Testing for these variants combined with all 21 previously identified using genetic sequencing identified men with a 10-fold higher risk of testicular cancer.
Drug for digestive problem can extend survival for many advanced cancer patients Advanced cancer patients given a drug designed to relieve constipation caused by pain killers lived longer with less tumor progression than those who did not receive or respond to the drug, researchers report. This is the first study in humans to associate opioid blockade with longer survival. It suggests that methylnaltrexone, approved in 2008 for prevention of opioid-induced constipation.
Inherited gene variation linked to an increased risk of the most common childhood cancer For two generations of one family, inherited variation in the ETV6 gene linked to an increased risk of childhood acute lymphoblastic leukemia.
3-D pancreatic cancer organoid may help predict clinical responses, personalize treatments A new method to grow 3-D organoid cultures of pancreatic tumors directly from surgical tissue offers a promising opportunity for testing targeted therapies and personalizing treatments.
New finding offers clues for blocking cancer gene A new study suggests a potential new way to block Notch, one of the most common cancer-causing genes, without causing severe side effects. The Notch gene plays a role in many types of cancer. It's the most common cancer-causing gene in T-cell acute lymphoblastic leukemia. About 60 percent of children and adults with T-cell leukemia harbor a Notch mutation

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