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Wednesday, April 22, 2015

Cancer Research: Scientists turn cancer cells into normal cells ♦ Breaking breast cancer resistance ♦ Radiotherapy after prostate cancer surgery declining

Cancer-inflammation 'vicious cycle' detailed in new study New findings hidden within the complex machinery behind the chronic inflammation-cancer feedback loop have been discerned.
New drug combination shows promise for breaking breast cancer resistance A new combination of drugs has been developed that may overcome treatment resistance and relapse in breast cancer. While most women initially respond well to hormonal treatment with drugs such as tamoxifen, many go on to develop resistance and relapse. There is evidence that this is often due to activation of  a gene involved which fuels the growth of the tumor.
Pancreatic cancer loses viral defenses when talking with supporting cells  Researchers have unlocked a way to make pancreatic cancer cells more vulnerable to cancer-killing viruses, known as oncolytic viruses. The scientists have discovered how they can exploit the communication, or cross-talk, between pancreatic cancer and a specific cell type that supports the tumor. This cross-talk weakens the ability of both cell types to fight off cancer-fighting viruses.
Pancreatic cancer breakthrough: Scientists turn cancer cells into normal cells  A new research study has shown that pancreatic cancer cells can be coaxed to revert back toward normal cells by introducing a protein called E47. E47 binds to specific DNA sequences and controls genes involved in growth and differentiation.

Use of radiotherapy after prostate cancer surgery declining, despite evidence of benefit Despite strong evidence and guidelines supporting its use, post-surgical radiation therapy for prostate cancer patients at risk of recurrence is declining in the United States. This study finds fewer than 10 percent of patients at risk of recurrence received postoperative radiotherapy

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