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Sunday, May 24, 2015

Cancer Research:New chemical technology for cancer therapy ♦ Molecular approach to promote cancer cell death ♦ Imaging technique identifies early metastasis in lymph nodes

New chemical technology boosts potency of targeted cancer therapy A new chemical technology uses cancer cell's' own protein-degrading machinery to destroy, rather than merely inhibit, cancer proteins. Researchers developed the strategy as a way to develop inhibitors of "undruggable" proteins and overcome drug resistance.
Study of advanced prostate cancer genome finds potential targets for drug therapy First study of the genomic composition of prostate cancer shows many patients have gene mutations that can be targeted with existing or potential drugs.
Scientists unveil prostate cancer's 'Rosetta Stone' Almost 90 percent of men with advanced prostate cancer carry genetic mutations in their tumors that could be targeted by either existing or new cancer drugs. Scientists now have created a comprehensive map of the genetic mutations within lethal prostate cancers that have spread around the body.
Researchers discover molecular approach to promote cancer cell death Lung cancer researchers have discovered a novel strategy to exploit apoptosis, a form of programmed cell death. The protein Bcl-2 is a known target for cancer treatment since it allows cancer cells to evade cell death via apoptosis.
Imaging technique identifies early metastasis in lymph nodes A highly sensitive imaging technique for non-invasive screening of lymph nodes for metastatic cancer has been developed by researchers. The new imaging technique -- so far tested in mice -- offers a rapid tool to noninvasively identify cancer's spread at its earliest stages.

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