Fatal Bacteremia Caused by Campylobacter gracilis.
Campylobacter species are well known to cause gastrointestinal infections in humans. However, extraintestinal illnesses caused by Campylobacter spp., including bacteremia, can also occur, primarily in immunocompromised persons. Campylobacter gracilis is a newly recognized species that is commonly found in the oral flora and that has been associated with periodontal diseases and pleuropulmonary infections. Furthermore, a wide range of infectious etiologies caused by C. gracilis at different anatomic sites have been reported in the literature, suggesting its highly pathogenic potential. We describe a case of bacteremia due to C. gracilis complicated by pneumonia.
An 80-year-old man with a history of hypertension, hypertensive nephropathy, and chronic obstructive pulmonary disease (COPD) was in his usual health status when he began having worsening productive cough, fevers, and malaise..He sought health care 5 days later at Long Island College Hospital . A heavy smoker who was noncompliant with his COPD treatment, he had frequent episodes of COPD exacerbation necessitating chronic maintenance with oral steroid therapy.
At physical examination, the patient appeared chronically ill and had mild respiratory distress. His temperature was 100.8°F, blood pressure 124/67 mm Hg, pulse 106 beats/min, respiration 22 breaths/min, and oxygen saturation 94% on room air. His heart sounds revealed tachycardia without murmurs, and his lung sounds disclosed scattered wheezing and rhonchi.
He was empirically given vancomycin, cefepime, and azithromycin. Severe respiratory distress developed, and the patient died a few days later. Respiratory cultures at that time showed Klebsiella pneumoniae and C. gracilis. Blood cultures were positive for C. gracilis.
C. gracilis is a nonmotile, non–spore-forming, anaerobic gram-negative rod that uniquely requires formate and fumarate in its metabolism. C. gracilis primarily inhabits the gingival crevice and has been associated with a wide variety of periodontal diseases
A study of 28 persons with chronic asymptomatic periradicular lesions showed C. gracilis in 6 , including 2 of 12 who had acute apical periodontitis and 4 of 17 who had acute periradicular abscess . C. gracilis has also been isolated from other anatomic sites and has caused severe infections such as peritonitis, pneumonia, and bacteremia
Our patient had C. gracilis bacteremia complicated by acute respiratory distress secondary to pneumonia. Although another gram-negative rod was isolated from the respiratory cultures, C. gracilis potentially played a major pathogenic role for this patient because of concomitant bacteremia that resulted in an unfavorable outcome. Pleuropulmonary infections with C. gracilis are not surprising because of the frequency of its detection in the human oral flora. In a study of 23 isolates of C. gracilis and their associated clinical diagnosis, 7 were from patients with lung abscess or empyema, and 2 were from those with aspiration pneumonia
Optimal antimicrobial drug treatment for C. gracilis remains to be established. Available antimicrobial susceptibility patterns in the literature have shown conflicting results. In 1 study, penicillin susceptibility was 67% and cephalosporin susceptibility was 67%–84% in 23 isolates of C. gracilis
Further research is warranted to elucidate the mechanisms of pathogenicity and virulence of C. gracilis. Its pathogenic potential should not be underestimated because of the spectrum of disease, severity of infection, and its possible high frequency of antimicrobial drug resistance.