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Wednesday, July 15, 2015

Bacterial Research:Basic computing elements created in bacteria ♦ C. difficile needs iron, but not too much: Insights into maintaining it 'just right' ♦ Using bacterial 'fight clubs' to find new drugs

Using bacterial 'fight clubs' to find new drugs Chemists have demonstrated that creating bacterial 'fight clubs' is an effective way to discover natural molecules with the potential to become new drugs. The "fight club" approach applies analytical tools to analyze what happens when microbes compete.
C. difficile needs iron, but not too much: Insights into maintaining it 'just right' Those bacteria that require iron walk a tightrope. Iron is essential for their growth, but too much iron can damage DNA and enzymes through oxidation. Therefore, bacteria have machinery to maintain their intracellular iron within a range that is healthy for them.
Basic computing elements created in bacteria Researchers unveil a series of sensors, memory switches, and circuits that can be encoded in the common human gut bacterium. These basic computing elements will allow the bacteria to sense, memorize, and respond to signals in the gut, with future applications that might include the early detection and treatment of inflammatory bowel disease or colon cancer,
Drug-resistant bacteria possess natural ability to become vulnerable to antibiotics Infections with one of the most troublesome and least understood antibiotic-resistant “superbugs” are increasing. But now scientists have shown the bacteria, A. baumannii, can naturally relinquish its defenses against antibiotics.
Multiple, co-existing groups of gut bacteria keep Clostridium difficile infections at bay Multiple species of bacteria working together in healthy guts are responsible for keeping out nasty bacterial invader, Clostridium difficile, a hospital-acquired culprit responsible for 15,000 deaths each year. The study could lead to tests to predict which hospital patients are at highest risk of infection and better management of infections.

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